Nucleocytoplasmic Transport: The Last 200 Nanometers
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چکیده
منابع مشابه
Nucleocytoplasmic Transport: The Last 200 Nanometers
only the receptor but also the adapter has to be recycled after transport of the substrate and therefore also shuttles between the nuclear and cytoplasmic compart-The data that gave rise to this skeletal description of D-69117 Heidelberg transport events has been reviewed extensively in the We refer the reader to these reviews for more detailed explanations and Introduction original references....
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Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GTPase Ran. The asymmetric distribution of Ran regulator proteins, RanGAP1 and RCC1, provides the driving force and directionality for nuclear transport.
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The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete interaction sites outside the central channel become apparent, and transport reg...
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ژورنال
عنوان ژورنال: Cell
سال: 1998
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80926-5